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Cartesio is sturdy 3d printer / desktop cnc design by Jos Scheepers with aluminum frame that you can buy or build yourself. It comes in two sizes: bigger Cartesio W and smaller Cartesio M.

Cartesio W description from the project page, it is priced at 2099 euro (Cartesio M is priced at 1699 euro):

The CartesioW V0.9 has a massive build volume of 400x200x200mm and comes standard with a 3D print extruder and a large Heated buildplatform
If you want other tools (engravers, plotters,...), please select them in the Tools catagory.
The Lead time for this product is currently : 3-6 weeks after payment has been received
We can also assemble Cartesio for you.

• Cartesio is a feature rich profesional CNC router.
• It supports a wide range of tools ig. 3D-print extruder and engraver.
• It is possible to print multiple colors, or materials.
• unique features :
• quiet printing
• very rigid build platform which does not move in X,Y direction.
• high precision GTM (gantry tool movement)
• automatic printhead cleaning
• large build volume of 400x200x200mm (X,Y,Z) M(edium)
• printable upgrades
• optional engraving tool with software speed control
• CDC (cable drag chains) cable protection

other features:

• stand alone printing
• moveable, due to its rigid design
• prints small and large detailed objects
• prints rigid construction elements
• high speed printing

http://reprap.org/wiki/Cartesio

Project homepage:

http://www.mauk.cc/

Cartesio wiki and building instructions:

http://www.mauk.cc/service.html

You can alos find them on Thingivers under:

http://www.thingiverse.com/jos/designs

http://www.thingiverse.com/thing:21664

CartesioW and smaller CartesioM comparison

From video description:

Just in time for the 2013 Holidays, HYREL 3D changes the economics of 3D printing with a single, affordable machine.
Whether one of HYREL's Engines or Systems, all are able to fabricate multiple parts simultaneously.

What this means to you:
If it currently takes four hours for your 3D printer to print / fabricate a single part and you need four of the same parts, it will take at least 16 hours total with a single machine.
With a single HYREL Engine or System, your capacity to fabricate parts simultaneously on the same machine opens up the bottleneck, saves you time and valuable shop space.
So, if you need two, three, or four fabricated parts... or if you need a small production run of parts...
... or if you'd like to mix in other materials with our different extruder heads -- you can do it all on your HYREL.

Other Materials include:
Sugru, Clay, Porcelain, Precious Metal Clay (PMC), Silicone RTV, Play-Doh, Plasticines... and coming soon, Wax, Chocolate, Cheese, Peanut Butter... etc.
For the material in the video, we used four colors of ABS. Each of the Mk1 Extruders in the video have been tested and verified to fabricate parts with the following types of filament: ABS, PLA, Nylon, PET, & Rubber. More filaments are currently being tested and more will be certified as 3D printable with the Mk1s in early 2014.

http://www.hyrel3d.com/

Interesting looking polar 3d printer developed by RepRap forum user unlimitedbacon. He calls it "3d printing record player". The rotating circular build plate is called the ϴ ("theta") axis and the swinging arm is called the R axis. They replace the  X and Y coordinates in a standard 3d printer.





























Features:

• 4 extruders for multiple colors and materials
• 320 mm print platter (meets or exceeds the area of current RepRaps)
• 80425 mm^2 print area
• 0.084 degrees/step angular resolution (ϴ Axis)
• 0.20 mm/step linear resolution (R Axis)
• it comes in two versions. The lasercut edition and the reprap edition (printed parts and threaded rods)

https://github.com/unlimitedbacon/Theta-Printer

Here is summary by Sanjay from Ultimaker forum: http://umforum.ultimaker.com/index.php?/topic/1877-e3d-all-metal-hotend-for-ultimaker/page-3

Concerning water cooled and multi-nozzle hotends

Because there seems to be a bit of speculation/confusion surrounding this I am going to let the cat out of the bag.
We have on the way a small prototype run of a 4 nozzled, water cooled, bowden fed hotends.
We are calling this new hotend "Kraken" - A multi tentacled water borne monster! 

The total footprint of the hotend is only 30*40mm in XY plane, the Z height from top to tip is under 40mm, and the 4 nozzles are arranged in a rectangle only 20mm*18mm apart. The weight without electronics looks to be around 110 grams, which is barely the weight of 2x E3Dv5 hotends. Each nozzle to have separate temperature control. Each nozzle can be individually levelled and adjusted in height to be planar with the bed in a very easy and quick way.

The small size and weight despite 4 nozzles is due mainly to the high efficiency of water cooling, even with only a tiny amount of water flow and a small cooling channel we still have a massive excess of cooling capacity. The second reason is a new way of mounting/gripping bowden tubes which has all the convenience and grip of pneumatic push-fit couplers, but with significantly less bulk and weight.

We intend to keep the price reasonable, and below the price for buying the equivalent number of E3Dv5.

But to be clear - Kraken is not a replacement for the normal v5 hotend, which will remain our main product that suits most users. The Kraken is designed purely for multi-nozzle bowden feed applications. Futhermore it is not finished! We will be shipping the majority of our beta prototyping run to trusted testers. I expect problems to occur and tweaks to be necessary. I will start a separate thread once things are ready, and the final version of Kraken will be developed in a public/interactive manner so the community can input what it wants/needs so that we can give you guys what you want.

Kraken will be open-source when sold publicly.

Cheers,
Sanjay

Update:

Here is the new E3D mixing extruder preview:

http://diy3dprinting.blogspot.com/2014/01/preview-of-e3d-filament-mixing-hotend.html

Here are detailed specifications:

http://3dmonstr.com/?q=content/3dmonstr-specifications


Price will be around 2500 USD from smaller machine.

On Kickstarter soon.


http://3dmonstr.com/




























Update (5/1/2013):

3dMonstr is on Kickstarter now:

http://www.kickstarter.com/projects/breytblat/3dmonstr-large-industrial-grade-quad-extruder-3d-p




3DMonstr key features:

• Its build volume is impressive. The smallest of its family is 1 cubic foot; the middle is 3.375 cubic feet, the largest is 8 cubic feet.

• It has four independent filament extruders, each with its own temperature control

• You can print small things on a big printer, but you can't print big things on a small one. That's why, whether you're printing large or small, we want to make sure that you could do so in fine resolution style, printing 40 micron layers.

• The extruders are attached to the machine via a QuickMount release making it really easy to switch them in and out and trivial to adjust their height. Just drop the extruder to the glass and go.

• 3DMonstr was built to last. It's like no 3D printer you've seen before. Made from industrial grade materials, it's incredibly sturdy and rigid. When people see this printer, they say, "Now this is serious."

• 3DMonstr printers are designed for future growth and built to last through rapidly changing technology. We wanted to build a structure that could push the limits of what future technology can throw at it because we want to be able to print more than plastic. After Kickstarter is over and the machines have been delivered, our focus will be on advanced extruders. That's why we needed to make sure we had a structure that could handle strong materials and high thermal stress.

• One of the biggest, ongoing frustrations and complaints of 3D printer users is the calibration process. It's not the kind of big we were going for, so we took the calibration solution a step further, and instead of trying to make calibration easier, we eliminated the problem by designing a large part of the problem right out of the printer.

• A nice touch is that 3DMonstr is foldable. This way, if you don't have a large workspace, you can fold it flat and tuck it away. You can also quickly remove the gantry from the table bed for easy transport. It comes apart and can be put together with no tools, in just a couple of minutes.

From video description:

We're revolutionizing personal manufacturing with this amazing all-in-one, networkable, four-color 3D printer and milling machine!
Makers making for makers: The Microfactory project began one year ago when four friends, longtime members of an independent maker space in Somerville, Massachusetts called Artisans Asylum, came together to create a better prototyping and machining tool....one that was easy to use, self-contained, and capable of a truly impressive list of tasks. They independently financed the development and testing of five full versions of the Microfactory, resulting in the exceptional product featured here. The Microfactory was entirely conceived, designed and built by people who have spent their lives around machines, who wanted to make something truly revolutionary and highly usable for makers everywhere.
Introducing the Microfactory: a networked, easy to operate, affordable, mess free, quiet, safe and fully-enclosed machine capable of:
printing functional parts in four colors or multiple materials
AND computerized etching
AND computer-controlled milling!
And check out some of the special features we've built in:
Port for a shop-vac hose so the machine "cleans up after itself" while it runs
Noise-reducing housing with safety-stop button
Full on-board computer -- no separate hardware or software needed! Connect and control through any (wired) network.
High-quality industry standard software built right in

http://www.mebotics.com/microfactory.html