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MTM Multifab is truly multifunctional desktop manufacturing machine that was very innovative and ground breaking in the field of  DIY 3d printing when it was developed. Ultimaker, very well known and powerful 3d printer,  is based on this machine.
Multifab has several replaceable tool head options:

• MACHINING SPINDLE, A high-speed (20K RPM) spindle supports light subtractive machining. The spindle can be constructed entirely from off-the-shelf compoents.
• VINYL CUTTER, A razor blade tool which allows 2D cutting of sheet material. Some applications are flexible circuit boards, stickers, silkscreen masks, and more.
• REPEATING PIPETTER, This fluid dispensing toolhead was created in collaboration with MIT's Innovations in International Health program, and has uses in automated biology research and disease diagnostics fabrication.
• PLOTTER HEAD, A pen attached to the multifab can allow easy labeling of objects, caligraphy, etc...
• 5 AXIS TRUNNION, This attachment permits 5-axis machining of components on the Multifab. Potential applications include variabl-helix screws, impellers, and 5-sided machining operations.
• PLASTIC EXTRUDER, Based on the Rep-Rap project, this extrusion head will enable additive manufacturing in plastics such as ABS.

MTM Multifab 3d printing

Here are some videos of Multifab in action writing and pipettering:





Demonstration of the MTM Multifab fitted with an auto-pipetting toolhead. The toolhead was designed with Amber Houghstow and Jose Gomez-Marquez of the MIT Innovations in International Health program, with the goal of automating production of XoutTB diagnostic assays. Perhaps it can also find a use in the DIY Bio community.
The MTM Multifab is part of the MIT Center for Bits and Atoms Machines That Make project.

Here is overview of Multifabs components, tools and development status:


http://mtm.cba.mit.edu/fabinabox/devmultifab.html

The instructions, plans and BOMs should be available for anyone who wants to build it, but all the files and documents links I tried on the site were broken. I hope it will be repaired soon, the public could benefit greatly with this machine.

Fab-in-a-Box

The Multifab is core machine of FAB in a Box framework system that should provide full digital fabrication environment that user could make at their home from simple parts. It contains:

Infrastructure. All of the key services which allow Fab-in-a-Box to be a cohesive toolset. These include the network, the box itself, power distribution, etc. It consist of the:

1. VIRTUAL MACHINE ENVIRONMENT, The flexible Fab-in-a-Box machine control and interface environment.  
2. THE NETWORK: FABNET, An RS485-based network is the nervous system of the toolset, which connects the "brain" - a laptop running control software - to the tools and sensors comprising Fab-in-a-Box. 
3. THE SUITCASE, The suitcase is the heart of the matter. It is what contains the entire fab in a box project.

Multifab. A computer-controlled multipurpose fabrication tool. Work includes integration into the box, the xyz motion stage, and multiple toolheads to perform various fabrication tasks. Multifab has many subsystems, components and parts:

Other Fab. All other tools needed to make something. Examples are the soldering iron, hand tools, and programming interfaces.

Measurement. Networked instrumentation such as a multimeter and oscilloscope. This is one area which will hopefully expand greatly on the road.

1. MULTIMETER, A multimeter which displays and records its readings on the Fab-in-a-Box laptop.
2. OSCILLOSCOPE, An oscilloscope which displays and records its readings on the Fab-in-a-Box laptop.

Autodoc. Everything related to making it possible to document a project "without thought".

1. EYE-FI CAMERA, A camera which wirelessly tranfers its time-stamped images to the Fab-in-a-Box auto-documentation software.
2. RFID READER, Keeping track of which hand tools were used, and when, is made easy with an RFID reader.

Some of the components were never developed, and most of the building related file links can not be opened. Probably all the files are somewhere on the internet, it would be terrible if they get lost forever. I REALLY hope someone publishes them as open source soon.


Here is the Fab-in-a-Box website:

http://mtm.cba.mit.edu/fabinabox/

PDF presentation:

http://mtm.cba.mit.edu/fabinabox/fabinabox.pdf

Save tons of money on your science equipment budget or start DIY science lab. It is easy ...

Open source lab homepage:

http://www.appropedia.org/Open-source_Lab

Here is a link to an open source calorimeter:

http://www.appropedia.org/Open-source_colorimeter

Here is the Thingiverse collection of 3d printable science instruments:

http://www.thingiverse.com/jpearce/collections/open-source-scientific-tools/page:1


You can build the 3d printer yourself as it is also open source, detailed instructions are available, check out the post about it here:

http://diy3dprinting.blogspot.com/2013/12/appropedia-most-delta-3d-printer.html


here is 3d printable open source spectrometer:

http://diy3dprinting.blogspot.com/2013/09/publiclaboratory-mobile-3d-printed.html

3d printable calorimeter

Printing blood vessels out of sugar at Uni Pennsylvania lab.


From video description:

Bioengineers have been steadily advancing toward the goal of building lab-grown organs out of a patient's own cells, but a few major challenges remain. One of them is making vasculature, the blood vessel plumbing system that delivers nutrients and remove waste from the cells on the inside of a mass of tissue. Without these blood vessels, interior cells quickly suffocate and die.
Scientists can already grow thin layers of cells, so one proposed solution to the vasculature problem is to "print" the cells layer by layer, leaving openings for blood vessels as necessary. But this method leaves seams, and when blood is pumped through the vessels, it pushes those seams apart.
Bioengineers from the University of Pennsylvania have turned the problem inside out by using a 3D printer called a RepRap to make templates of blood vessel networks out of sugar. Once the networks are encased in a block of cells, the sugar can be dissolved, leaving a functional vascular network behind.
"I got the first hint of this solution when I visited a Body Worlds exhibit, where you can see plastic casts of free-standing, whole organ vasculature," says Bioengineering postdoc Jordan Miller.
Miller, along with Christopher Chen, the Skirkanich Professor of Innovation in the Department of Bioengineering, other members of Chen's lab, and colleagues from MIT, set out to show that this method of developing sugar vascular networks helps keep interior cells alive and functioning.
After the researchers design the network architecture on a computer, they feed the design to the RepRap. The printer begins building the walls of a stabilizing mold. Then it then draws filaments across the mold, pulling the sugar at different speeds to achieve the desired thickness of what will become the blood vessels.
After the sugar has hardened, the researchers add liver cells suspended in a gel to the mold. The gel surrounds the filaments, encasing the blood vessel template. After the gel sets it can be removed from the mold with the template still inside. The block of gel is then washed in water, dissolving the remaining sugar inside. The liquid sugar flows out of the vessels it has created without harming the growing cells.
"This new technology, from the cell's perspective, makes tissue formation a gentle and quick journey," says Chen.
The researchers have successfully pumped nutrient-rich media, and even blood, through these gels blocks' vascular systems. They also have experimentally shown that more of the liver cells survive and produce more metabolites in gels that have these networks.
The RepRap makes testing new vascular architectures quick and inexpensive, and the sugar is stable enough to ship the finished networks to labs that don't have 3D printers of their own. The researchers hope to eventually use this method to make implantable organs for animal studies.
Text by Evan Lerner
Video by Kurtis Sensenig

via: http://go3dprinting.tumblr.com/

http://www.upenn.edu/spotlights/rep-rap-3d-printing-blood-vessel-networks

Ultra-uber-cool! I hope for more improvements, final success in building it and that they open source it.

From project page:

The Challenge: “In one week, can 32 young scientists and designers from China and the UK develop a new type of low-cost scanning probe microscope, powerful enough to study the nano world? And can this device transform science education in Chinese high schools? Tsinghua University, Peking University and University College London team up with the LEGO Foundation to invent, make and market their ideas”
Experts said they couldn't do it… THEY NEARLY DID!

http://www.instituteofmaking.org.uk/blog/2013/09/lego2nano-the-lego-microscope-challenge

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Version 4



From thingiverse pages:

This spectrometer is a scientific tool that straps onto an Android or iOS phone, tablet, or any camera capable of focusing very close (macro-mode) and allows you to collect spectra. Why would you want one? You can use it to identify the elemental composition of things (light bulbs, olive oil, beer, etc) based on the colors of light they emit. You can even use it to monitor your home brewing progress (http://bit.ly/Xyor6B).

http://www.thingiverse.com/thing:49934 (version 3)

http://www.thingiverse.com/thing:125428 (version 4)



Here is video describing their idea and scenarios for using DIY spectrometer:




They had a successful Kickstarter campaign:

http://www.kickstarter.com/projects/jywarren/public-lab-diy-spectrometry-kit


Spectral workbench is a place to archive, share, and interpret spectral data.

http://spectralworkbench.org/





Different model of 3d printed spectrometer:

http://diy3dprinting.blogspot.com/2013/09/tricorder-project-3d-printable.html

From the Tricorder project comes small 3d printable DYI science instrument.


























From project website:

The prototype spectrograph is an experiment in low-cost design, and is almost entirely 3D printed using ABS plastic on an inexpensive desktop 3D printer (such as a Makerbot, though I used an ORD Bot Hadron). I have much more experience designing electronics than I do designing optical systems, and so the spectrograph is designed to be swappable/upgradable as newer designs come to pass (and I expect it to go throught a few iterations). This first spectrograph design has a 3D printed slit, and uses an inexpensive 1000-line/mm diffraction grating of the kind you can find on diffraction grating slides for classroom experiments. I read a paper a while ago on using deconvolution to post-process the data from slit spectrometers and basically sharpen the point-spread function (or PSF) to effectively increase the resolution of the instrument. Inspired by this, I decided to leave out the relay optics between slit-to-grating and from grating-to-detector to see if I could use post-processing to effectively sharpen up the overly broad PSF and have an even simpler and less expensive instrument.
The spectrograph design:

• contains a ~0.2mm printed slit

• 400-700nm (approx) spectral range

• Variable spectral resolution (~3.3nm @400nm, ~1.8nm @ 700nm), not accounting for the PSF

• 1000 line-per-mm diffraction grating (cut into a 4mm wide strip, and inserted into the spectrograph flush with the slit aperture)

• 3D printable on an inexpensive printer

• Very small size — about 1cm wide x 2cm long x 3cm tall.

With a spectrometer you’re often battling for SNR, and have to worry about stray light. Although these pictures don’t show it, the spectrograph has to be spray painted with a flat matte black paint to get any kind of performance.

http://www.tricorderproject.org/blog/?p=206

http://www.thingiverse.com/thing:148270


Here is the PublicLab version of 3d printable spectrometer:

http://diy3dprinting.blogspot.com/2013/09/publiclaboratory-mobile-3d-printed.html